Frequently Asked Questions
What is a normal anion gap?
A typical reference range is about 8 to 12 mEq/L, though it varies by laboratory and whether potassium is included in the calculation.
What does a high anion gap mean?
A high anion gap can point to causes such as lactic acidosis, ketoacidosis, kidney failure, or certain toxins. It should always be interpreted with the full clinical picture.
What is the delta-delta ratio and when is it used?
The delta-delta (or delta ratio) compares the increase in anion gap to the decrease in bicarbonate: (AG − 12) / (24 − HCO₃). A ratio below 0.4 suggests a pure non-anion-gap acidosis; 0.4–0.8 suggests a mixed picture; 1–2 is consistent with a pure elevated anion gap acidosis; above 2 suggests a concurrent metabolic alkalosis masking the bicarbonate drop. It helps unmask mixed acid-base disorders that a simple anion gap calculation alone would miss.
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This calculator provides general health information only and is not medical advice. Results do not replace professional medical evaluation or diagnosis. Consult a licensed healthcare provider before making health decisions. Always seek immediate medical attention for emergencies.