Frequently Asked Questions
How much weight loss can I expect on GLP-1 medications?
Average results from Phase 3 trials: Wegovy (semaglutide 2.4mg) - 14.9% body weight loss at 68 weeks (STEP-1). Zepbound (tirzepatide 15mg) - 20.9% at 72 weeks (SURMOUNT-1). Mounjaro for diabetes - slightly less. Individual results vary widely: ~30% lose >20%, ~35% lose 10-15%, ~35% lose <10%. Most loss occurs in the first 6-9 months, then plateaus. Adherence and dose are the biggest predictors.
What happens when I stop taking GLP-1 medications?
Most people regain a substantial portion of lost weight. The STEP-4 trial showed that stopping semaglutide led to regaining about two-thirds of lost weight within 1 year. GLP-1 medications appear to be a long-term (likely lifetime) treatment for most patients, not a short-term diet aid. Lifestyle changes (diet, exercise, behavioral therapy) maintained during treatment substantially reduce rebound risk.
What are the common side effects?
Gastrointestinal: nausea (40-60% of patients), vomiting (10-25%), diarrhea, constipation. Usually most severe during dose escalation and improve over weeks. Rare but serious: pancreatitis, gallbladder issues, thyroid concerns (only in animal studies for some drugs), and severe gastroparesis. About 5-15% discontinue due to side effects. Slow dose titration reduces adverse events.
Is GLP-1 weight loss covered by insurance?
Coverage is highly variable. Diabetes prescriptions (Ozempic, Mounjaro) are widely covered. Weight-loss-only prescriptions (Wegovy, Zepbound) are covered by some employer plans but routinely denied by others. Medicare does not cover GLP-1s for weight loss as of 2026. Out-of-pocket cash prices: $1,000-$1,400/month. Compounded versions are sometimes available at lower cost but face FDA scrutiny and quality concerns. **This calculator provides estimates only - consult your physician.**
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General information only. Not medical advice.
Health & Medical Disclaimer: General information only. Not medical advice.
This calculator provides general health information only and is not medical advice. Results do not replace professional medical evaluation or diagnosis. Consult a licensed healthcare provider before making health decisions. Always seek immediate medical attention for emergencies.